本硕授课课程： 讲授本科生课程：学科前沿专题课程 讲授研究生课程：学科前沿专题课程 纵向课题： 1. 山东省重点研发计划（乡村振兴科技创新提振行动计划），2024TZXD067，黄精高效利用关键技术创新及应用示范，2024/11-2027/10，项目负责人 2. 山东省科学技术厅/山东省重点研发计划（科技示范工程）项目，2022SFGC0105，合成生物全产业链评价评估和标准体系建设，2022/11-2025/12，项目负责人 3. 济南市科技局/济南市“新高校20条”资助项目，202228088，生物信息指导下活性天然产物的定向制备，2023/01-2025/12，项目负责人 4. 齐鲁工业大学（山东省科学院）/科教产“揭榜制”项目，2022JBZ01-06，生物智能制造关键技术及应用示范，2022/08-2024/08，项目负责人 5. 高端外国专家引进计划，G2021023002L，生物正交性异源核酸的高效制备，2021/1/1-2022/12/31，项目负责人
6. 山东省自然科学基金创新发展联合基金项目，ZR2021LSW022，抗阿尔茨海默药物先导化合物的异源生物合成与作用机理研究，2022/1-2024/12，项目负责人
7. 泰山学者青年专家岗位，2021/1-2025/12，项目负责人
8. 济南市“新高校20条”，2021GXRC062，海参活性肽的挖掘，2022/1/1-2024/12/31，张立新主持，夏雪奎2
9. 国家自然科学基金面上项目，No.31770024，表观遗传调控下毛壳菌来源的抗MRSA活性次级代谢产物的发现及活性评价，2018/01-2022/12，项目负责人
10. 国家重点研发计划，2017YFF0209900，家用环境净化产品关键性能及安全性检测技术研究，子课题2，空气净化产品整机性能及安全性检测方法研究，2017/09-2020/12，共同负责人
11. 国家重点研发计划，2017YFF0209900，家用环境净化产品关键性能及安全性检测技术，子课题4，净水部件关键性能及安全性检测技术研究，2017/09-2020/12，共同负责人
12 .山东省自然科学基金面上项目，No.ZR2017MH025，毛壳科真菌来源的硫代化合物的发现和抗耐药菌活性的研究，2017/08-2019/07，项目负责人
13. 山东省自然科学基金重大基础研究项目，ZR2017ZB0206，黄花蒿共生微生物过氧桥键基因元件及作用机制的研究，2017/08-2019/07，张立新主持，夏雪奎2
14. 张立新泰山学者岗位，2016/01-2020/12，泰山突击队队长
15. 山东省科学院首届杰青，海洋生物及其共附生微生物协同抗肿瘤、抗菌活性的研究，2015/01-2017/12，项目负责人
16. 山东省科学院创新工程，抗耐药菌活性物质的发现及活性评价，2016/09-2019/09，核心成员
17. 山东省科学院博士基金，海参共附生微生物及其活性物质的研究，2009/01-2012/12，项目负责人
18. 山东省科学院基础研究计划（国家面上项目、省面上项目、省重点研发计划配套） 共3项， 2018/01-2018/12，项目负责人
19. Sanghee Shim（沈相姬）山东省科学院高层次人次项目，2018/01-2018/12
20. 齐鲁工业大学（山东省科学院）青年博士合作基金项目，2017BSHZ016，特境环境下抗耐药菌活性物质的挖掘，2018/01-2019/12，合作导师
21. 齐鲁工业大学（山东省科学院）青年博士合作基金项目，2019BSHZ0020，凝结芽孢杆菌中新型细菌素的鉴定和作用机制研究，2020/01-2021/12，合作导师
22. 山东省科学院国际合作项目，2019GHPY07，激活微生物沉默基因簇发现具有抗耐药菌活性的化合物，2019/1-2020/12，项目负责人 主要论文： 1. Haihong Chen, Yaohong Wang, Weishan Wang, Ting Cao, Lu Zhang, Zhengduo Wang, Xuran Chi, Tong Shi, Huangwei Wang, Xinwei He, Mindong Liang, Mengxue Yang, Wenyi Jiang, Dongyuan Lv, Jiaming Yu, Guoliang Zhu, Yongtao Xie, Bei Gao, Xinye Wang, Xueting Liu, Youyuan Li, Limin Ouyang, Jingyu Zhang, Huimin Liu, Zilong Li, Yaojun Tong, Xuekui Xia, Gao-Yi Tan, Lixin Zhang. High-yield porphyrin production through metabolic engineering and biocatalysis. Nature Biotechnology, 2024, doi: 10.1038/s41587-024-02267-3. (IF: ) (27/29) 一区（第四单位） 2. Chunlei Li, Ziyi Zhou, Weitao Wang, Yanqiu Zhao, Xin Yin, Yiwei Meng, Peipei Zhao, Mengmeng Wang, Xueting Liu, Xinye Wang, Shenlin Wang, Biao Ren*, Lixin Zhang*, and Xuekui Xia*. Development of Antibacterial Peptides with Membrane-Disruption and Folate Pathway Inhibitory Activities against Methicillin-Resistant Staphylococcus aureus. J. Med. Chem., 2024, 67(2):1044-1060. (IF：6.8) (14/14) 通讯作者. 一区（第一单位） 3. Guorui Gao, Shiping Luo, Yanqiu Zhao, Wanting Zhang, Mengnan Li, Yanyu Cao, Yu Ma, Xuekui Xia*, Bo Tang*. A metal-organic framework with chemodynamic performance self-synergistic efficient near-infrared photothermal activities for in vivo antibacterial application. Chemical Engineering Journal, 2024, 500: 157416. (IF：13.3) (8/9) 通讯作者. 一区（第二单位） 4. Min Liao, Xuekui Xia, Qingzhou Meng, Chengguang Zhu, Binyou Liao, Jiannan Wang, Lichen Gou, Xuedong Zhou, Wenpeng Yuan, Lei Cheng, Biao Ren. Holotoxin A1 from Apostichopus japonicus inhibited oropharyngeal and intra-abdominal candidiasis by inducing oxidative damage in Candida albicans. Br J Pharmacol., 2024, 181(12):1857-1873. (IF：6.8) (2/11) 共同第一作者. 一区（第三单位） 5. Peipei Zhao, Shengling Cao, Jiahui Wang, Jiaying Lin, Yunzeng Zhang, Chengwei Liu, Hairong Liu, Qingqing Zhang, Mengmeng Wang, Yiwei Meng, Xin Yin, Jun Qi, Lixin Zhang*, Xuekui Xia*. Activation of secondary metabolite gene clusters in Chaetomium olivaceum via the deletion of a histone deacetylase. Appl Microbiol Biotechnol., 2024, 108(1):332. (IF：5.0) (14/14) 通讯作者. 二区（第一单位） 6. Xin Yin, Yiwei Meng, Chenghong Sun, Yanqiu Zhao, Weitao Wang, Peipei Zhao, Mengmeng Wang, Jingli Ren, Jingchun Yao*, Lixin Zhang, Xuekui Xia*. Investigation of anti aging and anti infection properties of Jingfang Granules using the Caenorhabditis elegans model. Biogerontology, 2024, 25(3):433-445. (IF：4.4) (11/11) 通讯作者. 一区（第一单位） 7. Yanqiu Zhao, Lujiang Hao, Yiwei Meng, Longfen Li, Weitao Wang, Rui Zhao, Peipei Zhao, Jiyuan Zhang, Mengmeng Wang, Jingli Ren, Lixin Zhang, Xin Yin*, Xuekui Xia*. Screening and heterologous expression of an antimicrobial peptide SCAK33 with broad-spectrum antimicrobial activity resourced from sea cucumber proteome. International Microbiology, 2024, doi: 10.1007/s10123-024-00595-7. (IF：2.3) (13/13) 通讯作者. 三区（第一单位） 8. Weitao Wang, Yiwei Meng, Xin Yin, Peipei Zhao, Mengmeng Wang, Jingli Ren, Jiyuan Zhang, Lixin Zhang, Yunqian Cui*, Xuekui Xia*. Novel heterologously expressed protein, AjPSPLP-3, derived from Apostichopus japonicus exhibits cell proliferation and migration activities. Protein Expression and Purification, 2024, 224:106577. (IF：1.4) (10/10) 通讯作者. 四区（第一单位） 9. 王佳慧;赵佩佩;秦梦飞;赵燕秋;刘成伟;夏雪奎*. CRISPR传感检测技术的研究进展. 生物工程学报. 2024, 40(2): 367-377. 10. Qing-Zhou Meng, Xin-Zhu Wang, Huan-Qin Dai, Israa Assani, Meng-Ting Zhang, Pei-Pei Zhao, Long-Fen Li, Xin Yin, Jun Qi, Yang Pan, Li-Xin Zhang* and Xue-Kui Xia*. A gene cluster encoding a nonribosomal peptide synthetase-like enzyme catalyzes c-aromatic butenolides. Journal of Asian Natural Products Research, 2024, 26(6): 681-689. (IF：1.3) (12/12) 通讯作者. 三区（第一单位） 11. Xinzhu Wang, Qingzhou Meng, Haiyan Chen, Xin Yin, Huanqin Dai, Peipei Zhao, Yang Pan, Xuekui Xia* & Lixin Zhang*. Secondary metabolites isolated from Penicillium christenseniae SD.84 and their antimicrobial resistance effects. Natural Product Research, 2024, 6:1-9. (IF：1.9) (8/9) 通讯作者. 三区（第一单位） 12. Haiyan Han, Chunyan Yu, Jianzhao Qi, Pengchao Wang, Peipei Zhao, Wenbing Gong, Chunliang Xie, Xuekui Xia* and Chengwei Liu*. High-efficient production of mushroom polyketide compounds in a platform host Aspergillus oryzae. Microb Cell Fact., 2023, 22(1):60. (IF：6.4) (8/9) 通讯作者. 一区（第二单位） 13. Weitao Wang, Qingzhou Meng, Longfen Li, Weiyi Meng, Xin Yin, Peipei Zhao, Mengmeng Wang, Jingli Ren, Xuekui Xia*, Chunlei Li*. CGD-1, a defensin-related peptide derived from marine Chinese medicine Ostreae concha, inhibits the Gram-negative bacteria by membrane attack. TMR Pharmacology Research, 2023, 3(2):10. (9/10) 通讯作者.（第二单位） 14. 孟艺伟，赵燕秋，孟庆洲，吴清华，曲昆玉，赵佩佩，王盟盟，赵祥祥，代焕琴，殷欣*，夏雪奎*. 秀丽隐杆线虫模型在抗衰老研究中的应用. 生物资源. 2023, 45(1):9~15. 15. Mengmeng Wang, Kunyu Qu, Peipei Zhao, Xin Yin, Yiwei Meng, Piet Herdewijn, Chao Liu,*, Lixin Zhang*, Xuekui Xia*. Synthesis and anticancer evaluation of acetylated lysine conjugated gemcitabine prodrugs. RSC Medicinal Chemistry, 2023, 14,1572. (IF：4.1) (9/9)通讯作者. 二区（第一单位） 16. Peipei Zhao, Hairong Liu, Qinghua Wu, Qingzhou Meng, Kunyu Qu, Xin Yin, Mengmeng Wang, Xiangxiang Zhao, Jun Qi, Yiwei Meng, Xuekui Xia*, Lixin Zhang*. Investigation of chetomin as a lead compound and its biosynthetic pathway[J]. Appl. Microbiol. Biotechnol., 2022, 106(8): 3093-3102. (IF：3.9) (11/12)通讯作者. 二区（第一单位）
17. Peipei Zhao, Qinghua Wu, Xuekui Xia, Shiyi Guo, Sizhong Shen, Yujue Wang, Aiyou Huang*. Metabolomic and proteomic responses of Phaeodactylum tricornutum to hypoxia[J]. J. Oceanol. Limnol., 2022, 10.1007/s00343-021-1232-5.
18. Xiachang Wang, Yuanyuan Lu, Khaled A. Shaaban, Guojun Wang, Xuekui Xia, Youjuan Zhu. Editorial: Bioactive Natural Products from Microbes: Isolation, Characterization, Biosynthesis and Structure Modification. Frontiers in Chemistry, 2022,10,883652.
19. Jiapeng Wang, Xuekui Xia, Peipei Zhao, Xi He, Susu Zhang, Zhenshang Xu*. High-level secretory production of lysostaphin in Escherichia coli mutant by codon optimization and atmospheric and room temperature plasma mutagenesis. LWT. 2022, 165:113744.
20. Jianzhao Qi, Haiyan Han, Shengnan Tan, Changli Liu, Pengchao Wang, Xuekui Xia, Jin-ming Gao*, Chengwei Liu*. Efficient production of cyclic dipeptide (Cyclo-TA) through heterologous expression in Aspregillus oryzae. Microbial Cell Factories. 2022, 21:1462021
21. Peipei Zhao, Meng Yang, Guoliang Zhu, Bo Zhao, Hong Wang, Hairong Liu, Xinzhu Wang, Jun Qi, Xin Yin, Lumin Yu, Yiwei Meng, Zhipu Li, Lixin Zhang*, Xuekui Xia*. Mollicellins S-U, Three New Depsidones from Chaetomium brasiliense SD-596 with Anti-MRSA Activities. Journal of Antibiotics. 2021(74): 317-323.
22. Yaojun Tong, Jingyu Zhang, Nuo Sun, Xiang-Ming Wang, Qi Wei, Yu Zhang, Ren Huang, Yingying Pu, Huanqin Dai, Biao Ren, Gang Pei, Fuhang Song, Guoliang Zhu, Xinye Wang, Xuekui Xia, Xiangyin Chen, Lan Jiang, Shenlin Wang, Liming Ouyang, Ning Xie, Buchang Zhang, Yuanying Jiang, Xueting Liu, Richard Calderone, Fan Bai, Lixin Zhang, Gil Alterovitz, Berberine reverses multidrug resistance in Candida albicans by hijacking the drug efflux pump Mdr1p, Science Bulletin, 2021, 66 (18): 1895-1905.
23. Xiangxiang Zhao, Zhengduo Wang, Bowen Yang, Zilong Li, Yaojun Tong, Yuhai Bi, Zhenghong Li, Xuekui Xia, Xiangyin Chen, Lixin Zhang, Weishan Wang, Gao-Yi Tan, Integrating PCR-free amplification and synergistic sensing for ultrasensitive and rapid CRISPR/Cas12a-based SARS-CoV-2 antigen detection, Synthetic and Systems Biotechnology, 2021, 6 (4): 283-291.
24. 赵佩佩，刘海溶，杨梦，王红，齐君，刘昌衡，夏雪奎*, 青霉菌组蛋白去乙酰化酶基因的敲除及其次级代谢产物变化. 山东科学,2021,34(1):22-27
25. 王红，殷欣，孟庆洲，曲昆玉，刘海溶，吴清华，杨梦，赵丽娅，戴美学，夏雪奎*，基因组信息指导下海参共附生Penicillium sclerotiorum SD-36嗜氮酮类化合物的挖掘. 中国海洋药物.
26. Peipei Zhao, Qinghua Wu, Xuekui Xia, Shiyi Guo, Sizhong Shen, Yujue Wang, Aiyou Huang*. Metabolomic and proteomic responses of Phaeodactylum tricornutum to hypoxia. J. Oceanol. Limnol., Accepted.2020
27. Xinzhu Wang, Liya Zhao, Chao Liu, Jun Qi, Peipei Zhao, Zhaoming Liu, Chunlei Li, Yingying Hu, Xin Yin, Xin Liu, Zhixin Liao*, Lixin Zhang* Xuekui Xia*. New Tetramic Acids Comprising of Decalin and Pyridones from Chaetomium Olivaceum SD-80A with Antimicrobial Activity. Frontiers in Microbiology, 2020,10(2958).
28. Jun Qi, Lan Jiang, Peipei Zhao, Haiyan Chen, Xiaopeng Jia, Liya Zhao, Huanqin Dai, Jiansen Hu, Changheng Liu, Sang Hee Shim, Lixin Zhang*, Xuekui Xia*. Chaetoglobosins and azaphilones from Chaetomium globosum associated with Apostichopus japonicus. Applied Microbiology and Biotechnology, 2020,104(4):1545-1553
29. Jun Qi, Peipei Zhao, Liya Zhao, Airong Jia, Changheng Liu, Lixin Zhang* and Xuekui Xia*，Anthraquinone Derivatives from a Sea cucumber-derived Trichoderma sp. Fungus with Antibacterial Activities, Chemistry of Natural Compound, 2020,56(1):112-114
30. Xinzhu Wang, Jun Qi, Peipei Zhao, Chao Liu, Meng Yang, Hong Wang, Yingying Hu, Zhixin Liao*, Xuekui Xia*, Bioactive alkaloids Stephania sinica showing anti-drug-resistance activity. Chemistry of Natural Compounds, 2020,56(3):572-575
31. Mindong Liang, Leshi Liu, Weishan Wang, Xiaoqian Zeng, Jiakun Liu, Loganathan Karthik, Guoliang Zhu, Linquan Bai, Chengjian Hou, Xiangyin Chen, Liming Ouyang, Xueting Liu, Bin Hu, Xuekui Xia, Yaojun Tong, Chunbo Lou, Gil Alterovitz,Gao-Yi Tan*, Li-Xin Zhang*, Simple cloning of large natural product biosynthetic gene cluster by CRISPR/Cas12a-mediated fast direct capturing strategy. bioRxiv 2020.06.25.170191 ; doi: https://doi.org/10.1101/2020.06.25.170191
32. Zhixing Cao, Jiaming Yu, Weishan Wang, Hongzhong Lu, Xuekui Xia, Hui Xu, Xiuliang Yang, Lianqun Bao, Qing Zhang, Huifeng Wang, Siliang Zhang，LixinZhang. Multi-scale data-driven engineering for biosynthetic titer improvement. Current Opinion in Biotechnology 2020, 65:205–212
33. Alexander Zakharenko*, Denis Romanchenko, Pham Duc Thinh, Konstantin Pikula1, Cao Thi Thuy Hang, Wenpeng Yuan, Xuekui Xia, Vladimir Chaika, V alery Chernyshev, Svetlana Zakharenko, Mayya Razgonova, Gyuhwa Chung, Kirill Golokhvast. Features and Advantages of Supercritical CO2 Extraction of Sea Cucumber Cucumaria rondosa japonica Semper, 1868. Molecules. 2020,25,4088
34. Fan Wu, Jing Zhang, Fuhang Song, Sanshan Wang, Hui Guo, Qi Wei, Huanqin Dai, Xiangyin Chen, Xuekui Xia, Xueting Liu, Lixin Zhang, Jin-Quan Yu, and Xiaoguang Lei*. Chrysomycin A Derivatives for the Treatment of Multi-Drug-Resistant Tuberculosis. ACS central science. 2020, 6, 928-938
35. 殷欣，孟艺伟，赵丽娅，齐君，夏雪奎，高翠玲. 室内新风空气净化系统微生物多样性研究. 山东科学, 2020,33(5):99-1052019
36. Han J , Zhang J , Song Z , Liu, M., Hu. J, Hou. C, Zhu. G, Jing. L, X.K. Xia, Ronald. J, Q.Y.J.Feng, L.X. Zhang, T.Hsiang, X.T.Liu. Genome- and MS-based mining of antibacterial chlorinated chromones and xanthones from the phytopathogenic fungus Bipolaris sorokiniana strain 11134. Applied Microbiology and Biotechnology, 2019. DOI: 10.1007/s00253-019-09821-z.
37. 刘乐诗，谭高翼，王为善，李珊珊，夏雪奎，刘昌衡，代焕琴，张嗣良，张立新. 微生物，高智商，大产业——合成生物学助力阿维菌素的高效智能制造. 2019, 生命科学, (5), 516-525.
38. C.L. Li, C.G Zhu, B. Ren, X. Yin, S. Shim, Y. Gao, J.H. Zhu, P.P. Zhao, C.H. Liu, R.M. Yu, X.k. Xia*, L.X.Zhang*. Two optimized antimicrobial peptides with therapeutic potential for clinical antibiotic-resistant Staphylococcus aureus. European Journal of Medicinal Chemistry. 2019, 183, 111686.
39. H.Q. Dai, X.T. Liu, J.Y. Zhang , G. Liu , Y. Zhuo, B.C. Zhang, C.L. Liu, S.S. Li, X.K. Xia, Y.J. Tong, Y.W. Liu, G. Alterovitz, G.Y. Tan L.X. Zhang. A CRISPR-Cas12a-derived biosensing platform for the highly sensitive detection of diverse small molecules. Nature Communications 2019, 10, 3672.
40. J.S. Hu, Z. Li, J.Y. Gao, H.T. He, H.Q. Dai, X.K. Xia, C.H. Liu, L.X. Zhang, F.H. Song New Diketopiperazines from a Marine-Derived Fungus Strain Aspergillus versicolor MF180151. Mar. Drugs, 2019, 17(5), 262.
41. S.H. Bang, C.Y. Lee, S. Kim, J.H. Song, K.S. Kang, S.H. T., Sang-Jip Nam, X.K. Xia*, S.H. Shim*. Neuroprotective Glycosylated Cyclic Lipodepsipeptides,Colletotrichamides A−E, from a Halophyte-Associated Fungus, Colletotrichum gloeosporioides JS419. J. Org. Chem., 2019, 84, 17, 10999-11006
42. C.L. Li, Y. Wen, Y. He, J.H. Zhu, X. Yin, J.N. Yang, L.X. Zhang*, L.Y. Song , X.K. Xia*, R.G. Yu. Purification and characterization of a novel β-1,3-glucanase from Arca inflata and its immune-enhancing effects. Food Chemistry, 2019, 290(30) , 1-9.
43. Y.Y. Hu, M.Y.Yang, J. Zhao, Z.X. Liao*, J. Qi, X.Z. Wang, W.J iang, X.K. Xia*. A Meroterpenoid Isolated From the Fungus Aspergillus sp. Natural Product Communications, 2019, 14(11): 1–3.
44. W.S. Wang, S.S. Li, Z.L. Li, J.Y. Zhang, K.Q. Fan, G.Y. Tan, G. Ai, S. M.Lam, G.H. Shui, Z.H.Yang, H.Z. Lu, P.J. Jin, Y.H. Li, X.Y. Chen, X.K. Xia, X.T. Liu, H. K. Dannelly, C.Yang, Y. Yang, S.L. Zhang, G. Alterovitz, W.S. Xiang, L.X. Zhang. Harnessing the intracellular triacylglycerols for titer improvement of polyketides in Streptomyces. Nature Biotechnology , 2019. DOI: 10.1038/s41587-019-0335-42018
45. J.Q. Cao, Y.P. Yao, K.Q. Fan, G.Y. Tan, W.S. Xiang, X.K. Xia, S.S. Li, W.S. Wang, L.X. Zhang Harnessing a novel capability of bacterial allosteric transcription factors for sensing diverse small molecules in vitro.Science Advance. 2018, 4: eaau4602. (IF=13.09) . 2017
46. J. Qi, B. Zhao, P.P. Zhao, C.H. Liu, L.X. Zhang*, X.K. Xia*. Isolation and Characterization of Antiangiogenesis Compounds from the Fungus Aspergillus Terreus Associated with Apostichopus japonicus. Natural Product Communication, 2017, 12(2), 261-262.
47. Q.G. Gao, G.Y. Tan, X.K. Xia, L.X. Zhang*. Learn from microbial intelligence for avermectins overproduction. Current Opinion in Biotechnology. 2017, 48,251-257.
48. J. Zhang, C. Liu, R.Z. Huang, H.F. Chen, Z.X. Liao, J.Y. Sun, X.K. Xia, F.X. Wang. Three new C-27-carboxylated-lupanetriterpenoid derivatives from Potentilla discolor Bunge and their in vitro antitumor activities. Plos One, 2017, 7,1-18. 发明专利： 1.夏雪奎，刘海溶，李春磊，张立新，刘昌衡，殷欣，孟艺伟，赵佩佩，孟武，王盟盟，赵祥祥，孟庆洲. 抗菌肽CGS7及其制备方法和应用. CN202210133652.7, 2022已授权
2.夏雪奎，李春磊，张立新，殷欣，齐君，赵佩佩，刘昌衡，孟艺伟，赵丽娅，韩雅，杨梦，王红，抗菌肽H5-P5及其制备方法和应用，CN 110156875 B，2020.08已授权
3.夏雪奎，张立新，刘昌衡，齐君，贾晓鹏，赵佩佩，赵博，赵丽娅.广谱抗耐药菌先导化合物及其制备和应用，ZL201710543346X，2019.07已授权
4.赵博，夏雪奎，张立新，刘昌衡，齐君，贾晓鹏，赵佩佩，赵丽雅，王歆竹，含氯化合物及制备方法和用途，ZL201710886336.06，2019.09已授权
5.夏雪奎，张立新，刘昌衡，齐君，贾爱荣，刘新，张永刚，张绵松，史亚萍，袁文鹏，抑制血管生成活性的化合物及其制备方法和应用，ZL201510912759，2017.9已授权
6.夏雪奎，刘昌衡，陈锡强，张永刚，刘新，袁文鹏，王小军，孟秀梅，张绵松.贾爱荣.抑制血管生成的化合物及其制备方法和应用，ZL 201010560318.7，2012.9.26已授权
7.夏雪奎，刘昌衡，唐聚德，张绵松，孙永军，王小军，袁文鹏，刘新，张永刚，胡炜，一种海参阿胶多肽营养制品及其制备方法，ZL 2010 1 0279291，2013.9.11已授权
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