本硕授课课程: 讲授本科生课程:科技发展与学科专业概论 讲授研究生课程:学科前沿专题课程 纵向课题: 1. 国家重点研发计划青年科学家项目“深海药物先导化合物心血管保护活性评价新技术研究(2022YFC2804600)”,主持; 2. 国家自然科学基金 “基于斑马鱼模型研究炎症状态下异烟肼经内质网应激-自噬通路诱发肝毒性的作用机制”(81703624),主持; 3. 国家自然科学基金重点基金“海绵中新型骨架杂萜的发现与治疗炎症性肠病的功能” (22137006),合作方负责人; 4. 国家自然科学基金地区基金“FXR/PPARα信号通路在补骨脂提取物所致胆汁淤积性肝损伤中的作用及相关机制研究”(82060782),合作方负责人; 5.山东省泰山学者青年专家项目“中药肝毒性物质基础与作用机制研究”(tsqn202211204),主持; 6. 山东省自然科学基金优秀青年基金“斑马鱼药物活性筛选与安全性评价”(ZR2020YQ60),主持; 7. 济南市"新高校20条"资助项目自主培养创新团队“药物早期安全性快速评价关键技术研究与应用” (2021GXRC047) ,主持; 8. 中央引导地方科技发展资金项目“肿瘤与心血管药物成药性及安全性规范化快速评估公共服务平台”(YDZX2021023),合作方负责人; 9. 山东省技术创新引导计划项目“三峡阳菊副产物饲料添加剂开发”(2020LYXZ017),主持; 10. 新疆维吾尔自治区重点实验室开放课题(省级项目)“基于TLR4/NLRP信号通路调控巨噬细胞炎性表型的香青兰总黄酮抗阿霉素心脏毒性机制研究”(2021D04017),主持; 11. 齐鲁工业大学(山东省科学院)科教产融合创新试点工程项目“基于斑马鱼模型的药物早期活性筛选与安全性评价关键技术研究”(2020KJC-ZD08),子课题负责人; 12.山东省自然基金“基于模式生物斑马鱼研究轻度炎症状态下的异烟肼肝脏毒性作用”(ZR2015YL010),主持; 13.山东省科学院青年科学基金“斑马鱼肝脏毒性评价体系的建立和斑马鱼肝脏毒性生物标志物的研究”(2013QN001),主持; 14.齐鲁工业大学(山东省科学院)科教产融合试点工程-培英项目“关联临床病症的中药肝毒性与保肝疗效精准评价关键技术研究(2022PYI016)”,主持。 主要论文: 1.Huiwen Zhang, Chen Sun, Qing Xia, Peihai Li, Kechun Liu, Yun Zhang*. Brevianamide F Exerts Antithrombotic Effects by Modulating the MAPK Signaling Pathway and Coagulation Cascade. Marine Drugs, 2024(10),439-439.(通讯作者) 2.Jing Yang,Jingcheng Zhao,Te Zheng,Jiashuo Zhou,Huiwen Zhang, Yun Zhang*.A Rapid Quantitative Assessment Method for Liver Damage Effects of Compounds Based on Zebrafish Liver Partition Area Ratio.Journal of applied toxicology : JAT. 2024(通讯作者) 3.Li Liu,Yayun Zhong,Te Zheng,Jingcheng Zhao,Shumin Ding,Jinpeng Lv,Yun Zhang*.Epimedin B exerts an anti-inflammatory effect by regulating the MAPK/NF-κB/NOD-like receptor signalling pathways.Fish & shellfish immunology, 2024, 109657-109657.(通讯作者) 4.Shu Yan Gao, Jing Cheng Zhao, Qing Xia, Chen Sun, Maimaiti Aili, Ainiwaer Talifu, Shi Xia Huo, Yun Zhang*, Zhi Jian Li. Evaluation of the hepatotoxicity of Psoralea corylifolia L. based on a zebrafish model. Frontiers in Pharmacology, 2024, 15.(通讯作者) 5.Yongna Cao, Fenghua Xu, Qing Xia, Kechun Liu, Houwen Lin, Shanshan Zhang,Yun Zhang*. The Peptide LLTRAGL Derived from Rapana venosa Exerts Protective Effect against Inflammatory Bowel Disease in Zebrafish Model by Regulating Multi-Pathways. Marine Drugs, 2024, 22 (3).(通讯作者) 6.Zang X, Wang Y, Han C, Cui L, Liu H, Tian S, Liu K, Li P, Sun C, Xia Q, Zhang Y*. 2-Acetamidophenol (2-AAP) Suppresses the Progression of Atherosclerosis by Alleviating Hyperlipidemia and Attenuating the Ferroptosis Pathway. Mar Drugs. 2024 Nov 13;22(11):513.(通讯作者) 7. Zhang Siyue, Wang Xixin, Yang Qing, Xia Qing, Zhao Ye, Zheng Xiaohui, Zhang Yun*, Liu Kechun*. Isopropyl 3-(3,4-dihydroxyphenyl)-2-hydroxypropanoate plays an anti-hypoxic role through regulating neuroactive ligand-receptor interaction signaling pathway in larval zebrafish. Biomedicine & Pharmacotherapy,2023,161.(通讯作者) 8. MA Rui-jiao, Maharajan Kannan, XIA Qing, ZHANG Shanshan, TU Pengfei, LIU Kechun, ZHANG Yun*. Kunxian Capsule Extract Inhibits Angiogenesis in Zebrafish Embryos via PI3K/AKT-MAPK-VEGF Pathway. Chinese Journal of Integrative Medicine,2023,29(02):137-145.(通讯作者) 9. Liu L, Yang Y, Yang F, Lin Y, Liu K, Wang X, Zhang Y*. A mechanistic investigation about hepatoxic effects of borneol using zebrafish. Human & experimental toxicology,2023,42.(通讯作者) 10. Zhang Changqing, Li Chenqinyao, Liu Kechun, Zhang Yun*. Characterization of zearalenone-induced hepatotoxicity and its mechanisms by transcriptomics in zebrafish model. Chemosphere. 2022 Dec;309(Pt 1):136637.(通讯作者) 11. Chenqinyao Li, Changqing Zhang, Chengyue Zhu, Jie Zhang, Qing Xia, Kechun Liu, Yun Zhang*. Inflammation aggravated the hepatotoxicity of triptolide by lipid metabolism disorder, oxidative stress, autophagy, and apoptosis in zebrafish. Front. Pharmacol. 2022. doi: 10.3389/fphar.2022.949312.(通讯作者) 12. Wang XX, Zou HY, Cao YN, Zhang XM, Sun M, Tu PF, Liu KC, Zhang Y*. Radix Panacis quinguefolii Root Extract Ameliorates Inflammatory Bowel Disease through Inhibiting Inflammation. Chin J Integr Med. 2022 Dec 17.(通讯作者) 13. Jia ZL, Zhu CY, Rajendran RS, Xia Q, Liu KC, Zhang Y*. Impact of airborne total suspended particles (TSP) and fine particulate matter (PM2.5)-induced developmental toxicity in zebrafish (Danio rerio) embryos. J Appl Toxicol. 2022;10.1002/jat.4325.(通讯作者) 14. Dongjie S, Rajendran RS, Xia Q, She G, Tu P, Zhang Y*, Liu K. Neuroprotective effects of Tongtian oral liquid, a Traditional Chinese Medicine in the Parkinson's disease-induced zebrafish model. Biomed Pharmacother. 2022 Feb 10;148:112706. (通讯作者) 15. Wang X, Wu F, Zou H, Yang Y, Chen G, Liu K, Zhang Y*, Liu L*. Neurodevelopmental toxicity of pyrazinamide to larval zebrafish and the restoration after intoxication withdrawal. J Appl Toxicol. 2022 Jan 31.(通讯作者) 16. Zhang Y, Xia Q, Wang J, Zhuang K, Jin H, Liu K. Progress in using zebrafish as a toxicological model for traditional Chinese medicine. J Ethnopharmacol. 2022 Jan 10;282:114638.(第一作者) 17. Zhang X, Han L, Li P, Zhang S, Zhang M, Li X, Chu J, Wang L, Tu P, Zhang Y*, Liu K. Region-Specific Biomarkers and Their Mechanisms in the Treatment of Lung Adenocarcinoma: A Study of Panax quinquefolius from Wendeng, China. Molecules. 2021 Nov 12;26(22):6829.(通讯作者) 18. Maharajan K, Xia Q, Duan X, Tu P, Zhang Y*,Liu K. Therapeutic importance of Zishen Yutai Pill on the female reproductive health: A review. J Ethnopharmacol. 2021 Dec 5;281:114523.(通讯作者) 19. Zhang Y, Jia Z, Rajendran RS, Zhu C, Wang X, Liu K, Cen J. Exposure of particulate matter (PM10) induces neurodevelopmental toxicity in zebrafish embryos. Neurotoxicology. 2021 Dec;87:208-218.(第一作者) 20. Zhuang K, Xia Q, Zhang S, Maharajan K, Liu K, Zhang Y*. A comprehensive chemical and pharmacological review of three confusable Chinese herbal medicine-Aucklandiae radix, Vladimiriae radix, and Inulae radix. Phytother Res. 2021 Dec;35(12):6655-6689.(通讯作者) 21. Chengyue Zhu, Kannan Maharajan, Kechun Liu, Yun Zhang*. Role of atmospheric particulate matter exposure in COVID-19 and other health risks in human: A review. Environ Res. 2021 May 4:111281.(通讯作者) 22.Xiuying Duan, Ruijiao Ma, Chung-Der Hsiao, Zhenzhou Jiang, Luyong Zhang, Yun Zhang*, Kechun Liu. Tripterygium wilfordii multiglycoside-induced hepatotoxicity via inflammation and apoptosis in zebrafish. Chinese Journal of Natural Medicines. 2021.19(10):750-757(通讯作者) 23. Li Liu, Fang-yan Wu, Cheng-yue Zhu, Hong-yuan Zou, Rui-qi Kong, Yu-kui Ma, Dan Su, Guo-qiang Song, Yun Zhang*, Ke-chun Liu*. Involvement of dopamine signaling pathway in neurodevelopmental toxicity induced by isoniazid in zebrafish. Chemosphere. 2021 Feb;265:129109.(通讯作者) 24. Qing Xia, Kechun Liu, Zhili Jia, Xiaobin Li, Shanshan Zhang, Liwen Han, Guijin Sun, Chung-Der Hsiao, Yun Zhang*. The hepatoprotective effects of squid gonad phospholipids on fatty liver disease in zebrafish. Food Bioscience, 2020, 35. (通讯作者) 25. Juan Cen, Zhi-li Jia, Cheng-yue Zhu, Xue-fang Wang, Feng Zhang, Wei-yun Chen, Ke-chun Liu, Sai-yu Li, Yun Zhang*. Particulate matter (PM10) induces cardiovascular developmental toxicity in zebrafish embryos and larvae via the ERS, Nrf2 and Wnt pathways. Chemosphere. 2020; 250:126288.(通讯作者) 26. Yun Zhang, Chao Wang, Zhi-li Jia, Rui-jiao Ma, Xue-fang Wang, Wei-yun Chen, Ke-chun Liu*. Isoniazid promotes the anti-inflammatory response in zebrafish associated with regulation of the PPARγ/NF-κB/AP-1 pathway. Chemico-Biological Interactions. 2020.(第一作者) 27. Wang Xue, Yang Xue-Liang, Liu Ke-Chun, Sheng Wen-Long, Xia Qing, Wang Rong-Chun, Chen Xi-Qiang, Zhang Yun*. Effects of streptozotocin on pancreatic islet β-cell apoptosis and glucose metabolism in zebrafish larvae. Fish physiology and biochemistry. 2020. 46(3):1025-1038.(通讯作者) 发明专利: 1.张云,曹永娜等.一种多肽LLTRAGL在制备预防和/或治疗炎症性肠病药物中的应用. 中国, ZL202410148937.7,2024-10-08.已授权 2.张云,曹永娜等.一种多肽GTSFTTTAER在制备预防和/或治疗炎症性肠病药物中的应用.中国, ZL202410147013.5,2024-07-23.已授权 3.张云,李宁等.海洋来源磷脂在制备防护雷公藤多苷造成肝损伤药物中的应用.中国, ZL202211185544.0,2023-11-24.已授权 4.张云,李风玲等.纯绿青霉醇在制备治疗炎症性肠病药物中的应用.中国, ZL202211553498.5,2023-08-25.已授权 5.张云,夏青等.一种基于生物效应的昆仙胶囊质量控制方法与应用.中国, ZL202210134225.0,2023-08-15.已授权 6.张云,王利振等.一种基于聚合氨基酸的多组分创面修复止血敷料及其应用.中国, ZL202111313043.1,2022-06-21.已授权 7.张云,刘可春等.一种快速评价化合物对斑马鱼肝脏功能损伤作用的方法.中国, ZL201510487139.8,2018-01-26.已授权 8.张云,刘可春等.一种筛选具有保护斑马鱼肝功能活性化合物的方法.中国, ZL201510486750.9,2018-07-24.已授权 9.张云,刘可春等.一种斑马鱼幼鱼取样器及其工作方法.中国, ZL2016101735803,2018-10-26.已授权 10.张云,刘可春等,一种用于斑马鱼胚胎与幼鱼显微观察拍照的装置.中国, ZL201520124364.0, 2015-06-17.已授权 11.张云,刘可春等,一种用于药物处理斑马鱼胚胎与幼鱼的专用培养装置.中国, ZL 201520111511.0, 2015-07-15.已授权 12.张云,刘可春等, 一种用于斑马鱼胚胎与幼鱼的便携式恒温培养装置.中国, ZL201620233007.2, 2016-08-03. 已授权 |